Cancer-induced skeletal muscle defects show sex-specific differences in severity with men performing poorly compared to women. Hormones and sex chromosomal differences are suggested to mediate these differences, but the functional skeletal muscle markers to document these differences are unknown. We show that the myogenic microRNA miR is a marker of sex-specific differences in cancer-induced skeletal muscle defects. Cancer-induced loss of circulating miR was more severe in men with bladder, lung, and pancreatic cancers compared to women with the same cancer types. In a syngeneic model of pancreatic cancer, circulating and skeletal muscle loss of miR was more severe in male mice compared to female mice.

The COVID pandemic exposed many systemic issues, but one that remains unaddressed, despite long-standing precarity, stems from the dangers encountered by Canadian sex workers. With the few legal safeguards in place, sex workers recount physical and sexual violence at an alarmingly frequent basis. In Canada, selling sex services is legal, but purchasing them is illegal — a catch that makes sustenance incredibly difficult for sex workers and their families. The federal government pedals this narrative, with prime ministers from Sir John A. The federal government has ignored the dangerous realities of prostitution in Canada, and their blatant disregard allows injustices against sex workers to continue.

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